May, 2019
The Lu group went on a camping trip at Yanqing, ~80 KM north of Beijing city. Apart from the camping experience, we also enjoyed BBQ, beer, and hiking. Please check out the album and find our footprints.
May, 2019
In this paper, we summarized recent work by us and many others on protein PEPylation, a term describing the chemical conjugation of synthetic polypeptides to protein drugs, and their pharmacological applications.
Please check it out
https://pubs.acs.org.ccindex.cn/doi/10.1021/acs.bioconjchem.9b00236
March, 2019.
Biosourced polythioesters open the door to both sustainable production practices and practical recycling, providing a new, green route to optical and photochemical plastics.
https://pubs.acs.org.ccindex.cn/doi/pdf/10.1021/jacs.9b00031
This work has been selected as ACS Editors’ Choice for Open Access, featured as the Front Cover Story, and also highlighted in Spotlights on Recent JACS Publications.
https://pubs.acs.org.ccindex.cn/doi/pdf/10.1021/jacs.9b02969
Feb. 2019
In this work, regulation of nanoparticle cellular uptake is achieved via the helical conformation and orientation of the anchoring polypeptides. Our results found that the helical polypeptide anchoring its C-terminus to the surface of the nanoparticles gave rise to significantly higher cellular internalization than all other control groups. This is a collaboration work with Prof. Lingdong Sun (PKU) and Prof. Xinghua Shi (Nanoctr). Congratulations to all of the coauthors!
Jan. 2019
Flexible polymers such as PEG are overwhelmingly preferred for protein drug conjugation. So, helix or coil, which polymer conformation would you choose for protein conjugation? Check the paper out and you may be surprised.
https://pubs.acs.org/doi/10.1021/acscentsci.8b00548
BTW, Yingqin has already published 4 high quality first-author papers and this is definitely not her last one in our group.
Big congratulations to Yingqin and all the coauthors.
Dec. 2018
Yingqin received two prestigious national students awards in one month: one is the ACS Shanghai Chapter Outstanding Graduate Research Award (one of the two first tier prize), and the other is Baxter China Young Investigator Award (First tier prize). She traveled to Shanghai and Suzhou to give her award lectures on Dec. 8th and 14th, respectively. Congratulations!
Oct, 2018.
Chong finishes his two-and-half-year term as a postdoc in our group and will join IBS in Ulsan Korea under the supervision of Prof. Bartosz Grzybowski. Chong has been a productive and incredible colleague. We wish him a bright future!
Oct, 2018.
By collaborating with Prof. Zi-Chen Li and Prof. Fusheng Du, the two groups developed a simple formulation leading to facile generation of tandem pH-responsive protein nanogels. This nanogel is able to deliver the cargo protein to the cytosol in a traceless fashion. This technology may help the delivery of numerous protein drugs acting on target intracellularly. The paper is available online now.
https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.201805287
July 31, 2018
Yuan Jingsong and Hou Yingqin won National Graduate Scholarship. In the meantime, Yingqin was also awarded the “ChemStar of CCME” during the contest.
Congratulations to their achievements and thank you for setting up the standard for the junior fellows.
July, 2018.
Sheng Kai, one of our best former undergraduate research assistants, finishes his technician appointment in our lab and will soon start his new journey in The Scripps Research Institute as a graduate student. Enjoy the sunshine and beach at La Jolla, and always do good science, Kai!