Lu Research Group

April, 2020.

Please check them out.

Collaboration work with Prof. Dehai Liang published in Soft Matter

Dongxiao Yin, Hao Wen, Guangqi Wu, Shaolu Li, Chenyang Liu, Hua Lu* and Dehai Liang*, "PEGylated gene carriers in serum under shear flow", Soft Matter, 2020, 16(9), 2301-2310.

https://pubs.rsc.org/en/content/articlelanding/2020/SM/C9SM02397F#!divAbstract

Collaboration work with Prof. Qian Li published in Small

Zhilei Ge, Linjie Guo, Guangqi Wu, Jiang Li, Yunlong Sun, Yingqin Hou, Jiye Shi, Shiping Song, Lihua Wang, Chunhai Fan, Hua Lu* and Qian Li*, "DNA Origami-Enabled Engineering of Ligand–Drug Conjugates for Targeted Drug Delivery", Small, 2020, 16(16), e1904857

https://onlinelibrary.wiley.com/doi/full/10.1002/smll.201904857

Collaboration work with Prof. Bradley Olsen published in Polymer Chemistry

Helen Yao, Kai Sheng, Jialing Sun, Shupeng Yan, Yingqin Hou, Hua Lu and Bradley D. Olsen*, "Secondary structure drives self-assembly in weakly segregated globular protein-rod block copolymers", Polym. Chem., 2020, 11(17), 3032-3045.

https://pubs.rsc.org/en/content/articlelanding/2020/py/c9py01680e#!divAbstract

Collaboration work with Prof. Zhibo Li published in CCS Chemistry

Yong Shen, Wei Xiong, Yongzheng Li, Zhichao Zhao, Hua Lu*, and Zhibo Li*, "Chemoselective Polymerization of Fully Biorenewable α-Methylene-γ-Butyrolactone Using Organophosphazene/Urea Binary Catalysts Toward Sustainable Polyesters", CCS Chem. 2020, 2, 620-630.

https://www.chinesechemsoc.org/doi/10.31635/ccschem.020.202000232

Congratulations to the authors!

April, 2020.

In this work, we, in a collaboration with Prof. Er-Qiang Chen, utilized 4-hydroxyproline as the feedstock for making functional aliphatic polyesters. The work opens up new opportunities for sustainable polymers and bioconjugation.

https://www.chinesechemsoc.org/doi/10.31635/ccschem.020.201900119

Jan. 2020.

The magic of FROZEN: rapid and highly controlled grafting-from synthesis of protein-polydisulfide conjugates. We developed an extremely simple solution to a great challenge in protein-polymer conjugation. The chemistry is so simple that even biologists can do it well. The conjugates made by this method is potentially useful in intracellular protein delivery, traceless release and protein purification. A patent has been filed besed on this technology.

https://pubs.acs.org/doi/pdf/10.1021/jacs.9b12937

Oct. 2019.

Xiong Wei developed a novel photo-responsive polypeptides bearing allyloxyazobenzene side-chains that are modifiable via various approaches. The polymer showed interesting liquid crystalline phase behaviors. Please click the following website and check it out. https://doi.org/10.1039/C9PY01106D

This is a nice collaboration with Prof. Shen Zhihao and Prof. Chen Erqiang within our department.

The paper is included as an invited paper for the special issue 2020 Polymer Chemistry Emerging Investigators.

July 2019.

Summer is here! The group took a 3-day-trip in the grassland nearby Beijing to celebrate the graduation of Dr. Jingsong Yuan and Dr. Yingqin Hou, who will soon start their postdoctoral research in U.S.A. We will miss them and wish them success in the future!

July 2019

Congratulations to Hao and our collaborators! In this paper, we report an enzyme cleavable protein-polypeptide conjugate that can simultaneously maintain long circulation and be activated in the tumor environment. Please check it out:

https://pubs.acs.org/doi/10.1021/acs.biomac.9b00560

June, 2019.

Guangqi developed a series of thermal and redox sensitive selenopolypeptides. Rapid and reversible redox controlled helix-coil transitions are realized. These polymers could be useful biomaterials for many applications. Stay tuned for more fun following works, come soon.

https://pubs.rsc.org/en/content/articlelanding/2019/CC/C9CC03767E#!divAbstract

May 2019

Big congratulations to the newly minted Dr. Yuan and Dr. Hou, the first two of many PhDs from the Lu group, a truly milestone. Please check out the landmark moment.

May, 2019

The Lu group went on a camping trip at Yanqing, ~80 KM north of Beijing city. Apart from the camping experience, we also enjoyed BBQ, beer, and hiking. Please check out the album and find our footprints.

May, 2019

In this paper, we summarized recent work by us and many others on protein PEPylation, a term describing the chemical conjugation of synthetic polypeptides to protein drugs, and their pharmacological applications.
Please check it out
https://pubs.acs.org.ccindex.cn/doi/10.1021/acs.bioconjchem.9b00236