Chu Wang 

Investigator, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University

Investigator, Synthetic and Functional Biomolecules Center (SFBC), Peking University

Investigator, Peking-Tsinghua Center for Life Sciences.

Education and Research Background

Chu Wang, born in 1977 in Harbin, China. Dr. Wang obtained his B.S. degree in Biology from University of Science and Technology of China (USTC) in 2001 and his Ph.D. degree with Professor David Baker in 2007 from University of Washington. He started postdoctoral training with Professor Benjamin F. Cravatt at The Scripps Research Institute in 2009 and is currently supported by NIH / NIEHS Pathways to Independence (K99/R00) postdoctoral award. He is expected to start his independent research programs at Peking University in December, 2013.

Research Direction and Achievements

My research program will focus on the development and application of multi-disciplinary tools in chemoproteomics, biochemistry, bioinformatics and computational structure biology to streamline efforts in the functional annotation of uncharacterized enzymes and drug design in the post-genomic era. Directions include: uncover novel amino acid sites in enzymes that are post-translationally regulated by endogenous reactive metabolites or drug molecules; 2) interrogate the underlying functional implications of such modifications and 3) develop computational tools to model and design protein-small molecule interactions.

Recent Publications

1. Wang C^#, Weerapana E, Blewett M, Cravatt BF^#. (2014) A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles. Nature Methods, 11:79-85.（#并列通讯作者）
2. Dix MM, Simon GM, Wang C, Okerberg E, Patricelli MP, Cravatt BF. (2012) Functional Interplay between Caspase Cleavage and Phosphorylation Sculpts the Apoptotic Proteome. Cell. 2012 150(2):426-40.
3. Martin BR, Wang C, Adibekian A, Tully SE, Cravatt BF. (2011) Global profiling of dynamic protein palmitoylation. Nat Methods. 2011 9(1):84-9.
4. Weerapana E*, Wang C*, Simon GM, Richter F, Khare S, Dillon MB, Bachovchin DA, Mowen K, Baker D, Cravatt BF. (2010). Quantitative reactivity profiling predicts functional cysteines in proteomes. Nature 468:790-5. (*, 并列第一作者)
5. Wang C, Vernon R, Lange O, Tyka M, Baker D. (2010) Prediction of structures of zinc-binding proteins through explicit modeling of metal coordination geometry. Protein Sci 19:494-506.
6. Wang, C.*, Schueler-Furman, O.*, Andre, I., London, N., Fleishman, S. J., Bradley, P., Qian, B. & Baker, D. (2007). RosettaDock in CAPRI rounds 6-12. Proteins 69, 758-63. (*, 并列第一作者)
7. Wang, C., Bradley, P. & Baker, D. (2007). Protein-protein docking with backbone flexibility. J Mol Biol 373, 503-19.
8. Schueler-Furman, O.*, Wang, C.* & Baker, D. (2005). Progress in protein-protein docking: atomic resolution predictions in the CAPRI experiment using RosettaDock with an improved treatment of side-chain flexibility. Proteins 60, 187-94. (*, 并列第一作者)
9. Wang, C.*, Schueler-Furman, O.* & Baker, D. (2005). Improved side-chain modeling for protein-protein docking. Protein Sci 14, 1328-39. (*, 并列第一作者)